Programme
Bandeau décoratif
8th DNA polymerases meeting
September 28th to October 1st, 2026
Institut Pasteur, Paris, France

 

 
Monday, September 28, 2026
Welcome (Registration Desk)
08.45 am-09.00 am
Opening remarks
09.00 am-09.15 am
DNA Polymerases and replisome – Human DNAP
09.15 am-10.35 am
Chair: Ivan Matic, Inserm, France
0
09.15 am

Structural determinants of DNA polymerase ε function

Erik Johansson
Department of Medical Biochemistry and Biophysics, Umeå University, Sweden
0
09.40 am

The POLE2 subunit of DNA polymerase ε - possible implications for cancer cell biology

Michal Dmowski
Institute of Biochemistry and Biophysics Polish Academy Sciences, Warsaw, Poland
0
10.05 am

Saturation genome editing-based high throughput functional assay of DNA polymerase epsilon exonuclease domain

Albain Chansavang
Functional Genomics of rare tumors Team, Institut Cochin, Paris, France Genomic Medicine of Tumors and Cancer Department, Hôpital Cochin, Paris, France
0
10.20 am

POLE2: Exploring Its Role in Cancer

Deepali Chaudhry
Laboratory of DNA Replication and Genome Maintenance, Institute of Biochemistry and Biophysics, Polish Academy of Science, Warsaw, Poland Doctoral School of Molecular Biology and Biological Chemistry, Warsaw, Poland
Coffee break
10.35 am-11.00 am
DNA Polymerases and Diseases – Human DNAP
11.00 am-12.30 pm
0
11.00 am

Transiently Initiated Mutagenesis

Thomas Kunkel
NIEHS, NIH, Durham, United States
0
11.25 am

Human DNA polymerase gamma possesses separate metal binding sites for polymerase and DNA unwinding functions

Whitney Yin
Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, United States
0
11.50 am

A dedicated motif in human polymerase gamma enables replication through DNA roadblocks during mtDNA replication

Rafael Fernandez-Leiro
Genome Integrity & Structural Biology, Spanish National Cancer Research Centre, CNIO, Spain
0
12.15 pm

Structural insights into HSV-1 origin unwinding by the viral proteins UL9 and ICP8

Tahir Tahirov
986070 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, United States
Lunch
12.30 pm-2.00 pm
DNA Polymerases & Engineering I
2.00 pm-3.30 pm
0
2.00 pm

Synthetic genetics: beyond DNA and RNA

Philipp Holliger
MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, United Kingdom
0
2.25 pm
Steve A Benner
Foundation for Applied Molecular Evolution, Alachua, United States
0
2.50 pm
Yannick Rondelez
Gulliver Laboratory, ESPCI Paris Université PSL, Paris, France
0
3.15 pm

Machine-Learning Guided Engineering of a Thermostable piPolB Enables High-Temperature Primer-Independent MDA

Victor Mateo-Caceres
Department of Biochemistry, Universidad Autónoma de Madrid, Madrid, Spain Instituto de Investigaciones Biomédicas Sols-Morreale (CSIC-UAM), Madrid, Spain
Coffee break
3.40 pm-4.00 pm
Function & Regulation of DNA Polymerases
4.00 pm-4.55 pm
Chair: Kelly Zatopek, New England Biolabs Inc., United States
0
4.00 pm

A 25 year odyssey with Primase-Polymerases: uncovering their diverse roles in genome maintenance

Aiden Doherty
Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, United Kingdom
0
4.25 pm

A novel DNA polymerase from pathogenic Escherichia coli strains with Microhomology mediated end Joining capacity

Miguel De Vega
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain
0
4.40 pm

Minimal Primase-like Terminal Transferase from Archaeal Viruses at the Root of RRM Evolution

Murielle Seif El Dahan
cell biology and virology of archaea, Institut Pasteur, Paris, France Architecture and Dynamics of Biological Macromolecules, Department of structural biology and chemistry, Institut Pasteur, Paris, France
Poster Session I + exhibitions
4.55 pm-6.40 pm
Wine & Cheese
6.45 pm-8.00 pm
Tuesday, September 29, 2026
DNA Polymerases & DNA repair – Pol theta I
09.00 am-10.20 am
Chair: Sylvie Doublié, University Vermont, United States
0
09.00 am

Coordination of Pol θ domain function and regulation of DNA end-joining

Richard Wood
Epigenetics & Molecular Carcinogenesis, UT MD Anderson, Houston, tx, United States
0
09.25 am

Structural Basis of Microhomology-Dependent and Error-Prone DNA Synthesis by DNA Polymerase θ

Yang Gao
Department of Biosciences, Rice University, Houston, United States
0
09.50 am

Mechanistic Basis for Theta-Mediated End Joining: Pol θ Recruitment Governs Repair Outcomes 

Noritaka Adachi
Yokohama City Univ., Yokohama, Japan
0
10.05 am

DNA Polymerase Theta Shapes the Immunogenicity of Mitochondrial DNA: A New Player in Inflammation

Camille Gelot
CEA-IBFJ-DRCM-LREV, CEA, INSERM, Université Paris Cité, Université Paris-Saclay, Fontenay aux Roses, France
Coffee break
10.20 am-10.55 am
DNA polymerases & Engineering II
10.55 am-12.25 pm
Chair: Marcel Hollenstein, Institut Pasteur, France
0
10.55 am

Engineering Polymerases for Applications in Synthetic Biology

John Chaput
Department of Pharmaceutical Sciences, University of California, Irvine, United States
0
11.20 am

Syntheses of Hypermodified Nucleic Acids and Aptamers with Engineered DNA Polymerases

Michal Hocek
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic
0
11.45 am

Engineered polymerases for manufacturing oligonucleotide therapeutics

Stefan Lutz
Codexis Inc., Redwood City, United States
0
12.10 pm

Chemoenzymatic Synthesis of Stereodefined Phosphorothioate Oligonucleotides by DNA Ligation

Erwann Lacombe
Structural biology, Bioorganic Chemistry of Nucleic Acids, Institut Pasteur, Paris, France
Lunch
12.30 pm-1.45 pm
Poster Session II + exhibition
1.45 pm-3.45 pm
DNA Polymerases & DNA repair – NHEJ
4.15 pm-5.35 pm
Chair: Marc Delarue, Institut Pasteur, France
0
4.15 pm

ATP-dependent mismatch verification by MutS through allosteric gating

Wei Yang
Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, United States
0
4.40 pm

Addition of RNA by DNA polymerases during repair of chromosome breaks by the NHEJ pathway: when does this occur, and why?

Dale Ramsden
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, United States Lineberger Comprehensive Cancer Center, Chapel Hill, United States
0
5.30 pm

Continuous DNA-end protection during DNA-PKcs-independent NHEJ in budding yeast revealed by cryo-EM

Sophia Missoury
Biologie Structurale et Chimie, Pasteur, Paris, France
0
5.45 pm

A novel POLL-mediated pathway for repairing TOP2-induced DNA DSBs

Jose F. Ruiz
Biochemistry and Molecular Biology, University of Seville, Sevilla, Spain
Wednesday, September 30, 2026
DNA Polymerase & DNA Repair - Pol theta II
09.30 am-10.25 am
0
09.30 am

Insights into the mechanisms of DNA double-strand break repair during mitosis.

Raphael Ceccaldi
26 rue d'Ulm, Institut Curie, Paris, France
0
09.55 am

Coordination of Polymerase Theta-Mediated Repair by the DNA Damage Response

Kelsey Duprey
UNC Chapel Hill, Chapel Hill, United States
0
10.10 am

High-LET Radiation Uncovers a Long-Deletion Signature of DNA Polymerase Theta–Mediated End Joining

Kei-Ichi Takata
Center for Genomic Integrity, Institute for Basic Science, Ulsan, South Korea Department of Biomedical Engineering, UNIST, Ulsan, South Korea
Coffee break
10.25 am-10.55 am
Bacterial DNA Polymerases
10.55 am-12.15 pm
Chair: Ludovic Sauguet, Institut Pasteur, France
0
10.55 am

Novel antibiotics targeting bacterial DNA polymerases

Meindert Lamers
Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands
0
11.20 am

Structure and Kinetic Mechanism of S. aureus DnaE: Implications for the Initiation of Okazaki Fragments in Gram-positive Bacteria

Janice Pata
Department of Biomedical Sciences, University at Albany, Albany, United States New York State Department of Health, Wadsworth Center, Albany, United States
0
11.45 am

Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication

Gabriel Antonio Minero
Interdisciplinary Center of Nanoscience, Aarhus University, Aarhus, Denmark
0
12.00 pm

An auxiliary DNA-binding module enables cold-adapted DNA synthesis by phage polymerase Efa

Michal Roman Szymanski
Structural Biology Laboratory , Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of Gdansk, Gdansk, Poland
Lunch
12.15 pm-1.45 pm
DNA Polymerases & TLS I
1.45 pm-2.40 pm
0
1.45 pm

Multilayer control of the highly mutagenic polymerase iota

Justyna McIntyre
Institute of Biochemistry and Biophysics Polish Academy Sciences, Warsaw, Poland
0
2.10 pm

DNA polymerase κ–mediated bypass of diverse glycidamide-derived DNA adducts and its possible contribution to mutagenesis in the lung, a carcinogenic target organ

Jun-Ichi Akagi
Division of Pathology, National Institute of Health Sciences, Japan, Kawasaki, Japan
0
2.25 pm

Acinetobacter baumannii encodes multiple mutagenically and biochemically active DNA polymerase V variants. 

Malgorzata Jaszczur
Department of Biological Sciences, University of Southern California, Los Angeles, United States
Free afternoon
3.00 pm-7.00 pm
Gala dinner
7.30 pm-11.00 pm
Thursday, October 1, 2026
DNA Polymerases & TLS II
09.00 am-10.20 am
0
09.00 am

REV3L cooperates with RTEL1 to safeguard telomere stability in mammalian cells

Patricia Kannouche
Paris-Saclay Université, CNRS-UMR9019, Institut Gustave Roussy, Villejuif, France
0
09.25 am

Rothia dentocariosa DNA polymerase PolA2 possesses translesion synthesis activity

Penny Beuning
Chemistry and Chemical Biology, Northeastern University, Boston, United States
0
09.40 am

DNA Pol V stimulates the activity of other TLS polymerases

Luisa Laureti
CRCM, CNRS, Marseille, France
Coffee break
09.55 am-10.50 am
DNA Polymerases & Technology – II
10.50 am-12.10 pm
Chair: Yannick Rondelez, Gulliver Laboratory, ESPCI Paris Université PSL, France
0
10.50 am

Rules of Engagement: Defining Polymerase Roles in Archaeal DNA Replication

Kelly Zatopek
New England Biolabs Inc., Ipswich, United States
0
11.15 am
Ludovic Sauguet
Institut Pasteur, Paris, France
0
11.40 am

Diversity and distribution of DNA polymerases in archaea

Česlovas Venclovas
Vilnius University, Vilnius, Lithuania
0
11.55 am

Molecular insights into protein priming by DNA polymerases

Purba Mukherjee
Chemistry, YSBL, University of York, York, United Kingdom
Concluding remarks
12.10 pm-12.25 pm
End of the conference
12.15 pm-1.00 pm


 

 

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