Monday, September 28, 2026
| Welcome (Registration Desk) |
| 08.45 am-09.00 am
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| Opening remarks |
| 09.00 am-09.15 am
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| DNA Polymerases and replisome – Human DNAP |
| 09.15 am-10.35 am
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| Chair: Ivan Matic, Inserm, France |
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09.15 am |
Structural determinants of DNA polymerase ε function
Erik Johansson Department of Medical Biochemistry and Biophysics, Umeå University, Sweden
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09.40 am |
The POLE2 subunit of DNA polymerase ε - possible implications for cancer cell biology
Michal Dmowski Institute of Biochemistry and Biophysics Polish Academy Sciences, Warsaw, Poland
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10.05 am |
Saturation genome editing-based high throughput functional assay of DNA polymerase epsilon exonuclease domain
Albain Chansavang Functional Genomics of rare tumors Team, Institut Cochin, Paris, France Genomic Medicine of Tumors and Cancer Department, Hôpital Cochin, Paris, France
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10.20 am |
POLE2: Exploring Its Role in Cancer
Deepali Chaudhry Laboratory of DNA Replication and Genome Maintenance, Institute of Biochemistry and Biophysics, Polish Academy of Science, Warsaw, Poland Doctoral School of Molecular Biology and Biological Chemistry, Warsaw, Poland
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| Coffee break |
| 10.35 am-11.00 am
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| DNA Polymerases and Diseases – Human DNAP |
| 11.00 am-12.30 pm
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11.00 am |
Transiently Initiated Mutagenesis
Thomas Kunkel NIEHS, NIH, Durham, United States
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11.25 am |
Human DNA polymerase gamma possesses separate metal binding sites for polymerase and DNA unwinding functions
Whitney Yin Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, United States
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11.50 am |
A dedicated motif in human polymerase gamma enables replication through DNA roadblocks during mtDNA replication
Rafael Fernandez-Leiro Genome Integrity & Structural Biology, Spanish National Cancer Research Centre, CNIO, Spain
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12.15 pm |
Structural insights into HSV-1 origin unwinding by the viral proteins UL9 and ICP8
Tahir Tahirov 986070 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, United States
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| DNA Polymerases & Engineering I |
| 2.00 pm-3.30 pm
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2.00 pm |
Synthetic genetics: beyond DNA and RNA
Philipp Holliger MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, United Kingdom
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2.25 pm |
Steve A Benner Foundation for Applied Molecular Evolution, Alachua, United States
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2.50 pm |
Yannick Rondelez Gulliver Laboratory, ESPCI Paris Université PSL, Paris, France
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3.15 pm |
Machine-Learning Guided Engineering of a Thermostable piPolB Enables High-Temperature Primer-Independent MDA
Victor Mateo-Caceres Department of Biochemistry, Universidad Autónoma de Madrid, Madrid, Spain Instituto de Investigaciones Biomédicas Sols-Morreale (CSIC-UAM), Madrid, Spain
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| Coffee break |
| 3.40 pm-4.00 pm
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| Function & Regulation of DNA Polymerases |
| 4.00 pm-4.55 pm
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| Chair: Kelly Zatopek, New England Biolabs Inc., United States |
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4.00 pm |
A 25 year odyssey with Primase-Polymerases: uncovering their diverse roles in genome maintenance
Aiden Doherty Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, United Kingdom
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4.25 pm |
A novel DNA polymerase from pathogenic Escherichia coli strains with Microhomology mediated end Joining capacity
Miguel De Vega Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain
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4.40 pm |
Minimal Primase-like Terminal Transferase from Archaeal Viruses at the Root of RRM Evolution
Murielle Seif El Dahan cell biology and virology of archaea, Institut Pasteur, Paris, France Architecture and Dynamics of Biological Macromolecules, Department of structural biology and chemistry, Institut Pasteur, Paris, France
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| Poster Session I + exhibitions |
| 4.55 pm-6.40 pm
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| Wine & Cheese |
| 6.45 pm-8.00 pm
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Tuesday, September 29, 2026
| DNA Polymerases & DNA repair – Pol theta I |
| 09.00 am-10.20 am
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| Chair: Sylvie Doublié, University Vermont, United States |
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09.00 am |
Coordination of Pol θ domain function and regulation of DNA end-joining
Richard Wood Epigenetics & Molecular Carcinogenesis, UT MD Anderson, Houston, tx, United States
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09.25 am |
Structural Basis of Microhomology-Dependent and Error-Prone DNA Synthesis by DNA Polymerase θ
Yang Gao Department of Biosciences, Rice University, Houston, United States
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09.50 am |
Mechanistic Basis for Theta-Mediated End Joining: Pol θ Recruitment Governs Repair Outcomes
Noritaka Adachi Yokohama City Univ., Yokohama, Japan
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10.05 am |
DNA Polymerase Theta Shapes the Immunogenicity of Mitochondrial DNA: A New Player in Inflammation
Camille Gelot CEA-IBFJ-DRCM-LREV, CEA, INSERM, Université Paris Cité, Université Paris-Saclay, Fontenay aux Roses, France
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| Coffee break |
| 10.20 am-10.55 am
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| DNA polymerases & Engineering II |
| 10.55 am-12.25 pm
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| Chair: Marcel Hollenstein, Institut Pasteur, France |
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10.55 am |
Engineering Polymerases for Applications in Synthetic Biology
John Chaput Department of Pharmaceutical Sciences, University of California, Irvine, United States
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11.20 am |
Syntheses of Hypermodified Nucleic Acids and Aptamers with Engineered DNA Polymerases
Michal Hocek Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic
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11.45 am |
Engineered polymerases for manufacturing oligonucleotide therapeutics
Stefan Lutz Codexis Inc., Redwood City, United States
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12.10 pm |
Chemoenzymatic Synthesis of Stereodefined Phosphorothioate Oligonucleotides by DNA Ligation
Erwann Lacombe Structural biology, Bioorganic Chemistry of Nucleic Acids, Institut Pasteur, Paris, France
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| Poster Session II + exhibition |
| 1.45 pm-3.45 pm
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| DNA Polymerases & DNA repair – NHEJ |
| 4.15 pm-5.35 pm
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| Chair: Marc Delarue, Institut Pasteur, France |
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4.15 pm |
ATP-dependent mismatch verification by MutS through allosteric gating
Wei Yang Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, United States
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4.40 pm |
Addition of RNA by DNA polymerases during repair of chromosome breaks by the NHEJ pathway: when does this occur, and why?
Dale Ramsden Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, United States Lineberger Comprehensive Cancer Center, Chapel Hill, United States
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5.30 pm |
Continuous DNA-end protection during DNA-PKcs-independent NHEJ in budding yeast revealed by cryo-EM
Sophia Missoury Biologie Structurale et Chimie, Pasteur, Paris, France
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5.45 pm |
A novel POLL-mediated pathway for repairing TOP2-induced DNA DSBs
Jose F. Ruiz Biochemistry and Molecular Biology, University of Seville, Sevilla, Spain
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Wednesday, September 30, 2026
| DNA Polymerase & DNA Repair - Pol theta II |
| 09.30 am-10.25 am
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09.30 am |
Insights into the mechanisms of DNA double-strand break repair during mitosis.
Raphael Ceccaldi 26 rue d'Ulm, Institut Curie, Paris, France
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09.55 am |
Coordination of Polymerase Theta-Mediated Repair by the DNA Damage Response
Kelsey Duprey UNC Chapel Hill, Chapel Hill, United States
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10.10 am |
High-LET Radiation Uncovers a Long-Deletion Signature of DNA Polymerase Theta–Mediated End Joining
Kei-Ichi Takata Center for Genomic Integrity, Institute for Basic Science, Ulsan, South Korea Department of Biomedical Engineering, UNIST, Ulsan, South Korea
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| Coffee break |
| 10.25 am-10.55 am
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| Bacterial DNA Polymerases |
| 10.55 am-12.15 pm
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| Chair: Ludovic Sauguet, Institut Pasteur, France |
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10.55 am |
Novel antibiotics targeting bacterial DNA polymerases
Meindert Lamers Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands
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11.20 am |
Structure and Kinetic Mechanism of S. aureus DnaE: Implications for the Initiation of Okazaki Fragments in Gram-positive Bacteria
Janice Pata Department of Biomedical Sciences, University at Albany, Albany, United States New York State Department of Health, Wadsworth Center, Albany, United States
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11.45 am |
Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication
Gabriel Antonio Minero Interdisciplinary Center of Nanoscience, Aarhus University, Aarhus, Denmark
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12.00 pm |
An auxiliary DNA-binding module enables cold-adapted DNA synthesis by phage polymerase Efa
Michal Roman Szymanski Structural Biology Laboratory , Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of Gdansk, Gdansk, Poland
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| DNA Polymerases & TLS I |
| 1.45 pm-2.40 pm
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1.45 pm |
Multilayer control of the highly mutagenic polymerase iota
Justyna McIntyre Institute of Biochemistry and Biophysics Polish Academy Sciences, Warsaw, Poland
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2.10 pm |
DNA polymerase κ–mediated bypass of diverse glycidamide-derived DNA adducts and its possible contribution to mutagenesis in the lung, a carcinogenic target organ
Jun-Ichi Akagi Division of Pathology, National Institute of Health Sciences, Japan, Kawasaki, Japan
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2.25 pm |
Acinetobacter baumannii encodes multiple mutagenically and biochemically active DNA polymerase V variants.
Malgorzata Jaszczur Department of Biological Sciences, University of Southern California, Los Angeles, United States
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| Free afternoon |
| 3.00 pm-7.00 pm
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| Gala dinner |
| 7.30 pm-11.00 pm
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Thursday, October 1, 2026
| DNA Polymerases & TLS II |
| 09.00 am-10.20 am
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09.00 am |
REV3L cooperates with RTEL1 to safeguard telomere stability in mammalian cells
Patricia Kannouche Paris-Saclay Université, CNRS-UMR9019, Institut Gustave Roussy, Villejuif, France
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09.25 am |
Rothia dentocariosa DNA polymerase PolA2 possesses translesion synthesis activity
Penny Beuning Chemistry and Chemical Biology, Northeastern University, Boston, United States
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09.40 am |
DNA Pol V stimulates the activity of other TLS polymerases
Luisa Laureti CRCM, CNRS, Marseille, France
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| Coffee break |
| 09.55 am-10.50 am
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| DNA Polymerases & Technology – II |
| 10.50 am-12.10 pm
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| Chair: Yannick Rondelez, Gulliver Laboratory, ESPCI Paris Université PSL, France |
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10.50 am |
Rules of Engagement: Defining Polymerase Roles in Archaeal DNA Replication
Kelly Zatopek New England Biolabs Inc., Ipswich, United States
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11.15 am |
Ludovic Sauguet Institut Pasteur, Paris, France
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11.40 am |
Diversity and distribution of DNA polymerases in archaea
Česlovas Venclovas Vilnius University, Vilnius, Lithuania
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11.55 am |
Molecular insights into protein priming by DNA polymerases
Purba Mukherjee Chemistry, YSBL, University of York, York, United Kingdom
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| Concluding remarks |
| 12.10 pm-12.25 pm
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| End of the conference |
| 12.15 pm-1.00 pm
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